Anne-Lise Pitel » Personnes

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Anne-Lise Pitel

MCU
UNICAENNeuropsychologie et neuroimagerie des troubles de l’usage d’alcool et du syndrome de Korsakoff / Neuropsychology and neuroimaging of alcohol use disorder and Korsakoff syndrome

Téléphone professionnel: +33(0)2 31 47 01 25 



Travail Centre Cyceron, Campus Jules Horowitz Boulevard Henri Becquerel BP 5229 Caen 14074 cedex 5


Site internet: Profil ResearchGate
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Informations biographiques

Mes travaux de recherche actuels portent sur le trouble de l’usage d’alcool et le syndrome de Korsakoff. Ils s’articulent autour de 3 objectifs :
– améliorer notre compréhension de la physiopathologie cognitive et cérébrale (Projet ANR ALCOBRAIN),
– examiner les facteurs influençant la sévérité et la nature des dysfonctionnements cérébraux (rôle du sommeil (Projet ALCOSLEEP) et de l’atteinte hépatique (Projet ANR ALCOBRAIN)),
– tester l’efficacité de la remédiation cognitive (Projet PHRC-I ALCOSTIM).

My current research projects concern alcohol use disorder and Korakoff syndrome. Their main objectives are:
-to improve our understanding of the cognitive and cerebral pathophysiology (ANR Project ALCOBRAIN),
-to examine the factors that could influence the nature and severity of the brain dysfunction (the role of sleep (ALCOSLEEP project) and liver disease (ANR Project ALCOBRAIN),
-to measure the efficacy of cognitive rehabilitation (PHRC-I ALCOSTIM Project).

10 principales publications/10 main publications:
1. Direct voxel-based comparisons between grey matter shrinkage and glucose hypometabolism in chronic alcoholism.
Ritz L, Segobin S, Lannuzel C, Boudehent C, Vabret F, Eustache F, Beaunieux H, Pitel AL.
J Cereb Blood Flow Metab. 2016 Sep;36(9):1625-40.
2. Integrity of white matter microstructure in alcoholics with and without Korsakoff’s syndrome.
Segobin S, Ritz L, Lannuzel C, Boudehent C, Vabret F, Eustache F, Beaunieux H, Pitel AL.
Hum Brain Mapp. 2015 Jul;36(7):2795-808.
3. Thalamic abnormalities are a cardinal feature of alcohol-related brain dysfunction.
Pitel AL, Segobin SH, Ritz L, Eustache F, Beaunieux H.
Neurosci Biobehav Rev. 2015 Jul;54:38-45.
4. Relationship between brain volumetric changes and interim drinking at six months in alcohol-dependent patients.
Segobin SH, Chételat G, Le Berre AP, Lannuzel C, Boudehent C, Vabret F, Eustache F, Beaunieux H, Pitel AL.
Alcohol Clin Exp Res. 2014 Mar;38(3):739-48.
5. Macrostructural abnormalities in Korsakoff syndrome compared with uncomplicated alcoholism.
Pitel AL, Chételat G, Le Berre AP, Desgranges B, Eustache F, Beaunieux H.
Neurology. 2012 Apr 24;78(17):1330-3.
6. Signs of preclinical Wernicke’s encephalopathy and thiamine levels as predictors of neuropsychological deficits in alcoholism without Korsakoff’s syndrome.
Pitel AL, Zahr NM, Jackson K, Sassoon SA, Rosenbloom MJ, Pfefferbaum A, Sullivan EV.
Neuropsychopharmacology. 2011 Feb;36(3):580-8.
7. Morphological and glucose metabolism abnormalities in alcoholic Korsakoff’s syndrome: group comparisons and individual analyses.
Pitel AL, Aupée AM, Chételat G, Mézenge F, Beaunieux H, de la Sayette V, Viader F, Baron JC, Eustache F, Desgranges B.
PLoS One. 2009 Nov 13;4(11):e7748.
8. Changes in the episodic memory and executive functions of abstinent and relapsed alcoholics over a 6-month period.
Pitel AL, Rivier J, Beaunieux H, Vabret F, Desgranges B, Eustache F.
Alcohol Clin Exp Res. 2009 Mar;33(3):490-8.
9. Episodic and working memory deficits in alcoholic Korsakoff patients: the continuity theory revisited.
Pitel AL, Beaunieux H, Witkowski T, Vabret F, de la Sayette V, Viader F, Desgranges B, Eustache F.
Alcohol Clin Exp Res. 2008 Jul;32(7):1229-41.
10. Genuine episodic memory deficits and executive dysfunctions in alcoholic subjects early in abstinence.
Pitel AL, Beaunieux H, Witkowski T, Vabret F, Guillery-Girard B, Quinette P, Desgranges B, Eustache F.
Alcohol Clin Exp Res. 2007 Jul;31(7):1169-78.

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